Fusobacterium nucleatum drives colorectal cancer progression through the circPTBP3/miR-760/PUM1 axis - PubMed
4 hours ago
- #circular RNA
- #colorectal cancer
- #Fusobacterium nucleatum
- Circular RNA circPTBP3 is upregulated in colorectal cancer (CRC) tissues and upon Fusobacterium nucleatum infection.
- F. nucleatum activates transcription factor ETS1 to preferentially transcribe circPTBP3 over its host gene PTBP3.
- CircPTBP3 promotes CRC cell proliferation and tumor growth both in vitro and in vivo.
- Mechanistically, circPTBP3 sponges miR-760, relieving its suppression of the downstream target PUM1.
- Clinically, circPTBP3 expression correlates positively with F. nucleatum abundance, PUM1 levels, larger tumor sizes, and advanced TNM stages, but negatively with miR-760.
- The study reveals a novel F. nucleatum-circPTBP3-miR-760-PUM1 regulatory axis driving CRC progression.