Herbal Medicines and Drugs Interactions: Cytochrome P450 Responsibility - PubMed
4 hours ago
- #Herb-drug interaction
- #Cytochrome P450
- #Pharmacovigilance
- Herbal medicines can interact with drugs, affecting their pharmacokinetics and pharmacodynamics, primarily through the cytochrome P450 (CYP450) enzyme system.
- The study evaluates how herbal remedies influence CYP450 enzyme activity, distinguishing between enzyme induction (reducing drug efficacy) and inhibition (increasing drug concentrations and toxicity).
- Ten plant species with significant effects on CYP450 were identified, including St John's wort, Echinacea, Ginkgo, Danshen, Garlic, Ginger, Milk thistle, Black cohosh, Ginseng, and Liquorice.
- The research highlights the need for awareness among healthcare professionals and patients about herb-drug interactions.
- Future steps include conducting standardized clinical trials, developing predictive models, and analyzing herbal constituents to ensure safe pharmacotherapy.