IL-2 synergizes with proinflammatory type 3 inducers to amplify mixed type 2-type 3 inflammation in nasal polyps - PubMed
3 hours ago
- #CRSwNP
- #IL-2
- #JAK-STAT
- IL-2 synergizes with type 3 inducers (TNF-α, IL-1β, IL-23) to amplify mixed type 2-type 3 inflammation in nasal polyps (CRSwNP).
- IL-2 levels are elevated in CRSwNP, especially in type 3-dominant and mixed type 2-type 3 subgroups, correlating with type 3 cytokines.
- RNA-seq data shows upregulated IL-2 receptors and co-expression with type 3 genes in nasal polyps.
- IL-2 and type 3 inducers synergistically enhance both type 2 and type 3 cytokine production in dispersed NP cells (DNPCs).
- CD8+ T cells in nasal polyps were identified as a novel source of IL-13.
- Memory T cells mediate TCR-independent cytokine production in response to IL-2 and type 3 inducers.
- Transcriptomic analysis reveals activated type 3, type 2, and JAK-STAT signaling pathways.
- IL-2 receptor blockade, particularly JAK inhibition, reduces synergistic inflammation.
- Targeted JAK inhibition is proposed as a potential therapy for CRSwNP.