Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation - PubMed
4 hours ago
- #Atrial Fibrillation
- #Left Atrial Appendage Closure
- #Stroke Prevention
- Study compares left atrial appendage closure (LAAC) with physician-directed best medical care for stroke prevention in atrial fibrillation patients at high risk for stroke and bleeding.
- Multicenter randomized trial in Germany with 912 patients (mean age 77.9 years, 38.6% women).
- Primary endpoint: composite of stroke, systemic embolism, major bleeding, or cardiovascular/unexplained death.
- LAAC did not meet noninferiority criteria compared to medical therapy (hazard ratio margin 1.3).
- Incidence of primary endpoint events: 16.8 per 100 patient-years (LAAC) vs. 13.3 (medical therapy).
- Serious adverse events occurred in 82.5% of LAAC patients and 77.4% of medical therapy patients.
- Conclusion: LAAC was not noninferior to medical therapy for high-risk atrial fibrillation patients.