Synchronous activation of striatal cholinergic interneurons induces local serotonin release - PubMed
4 hours ago
- #neuroscience
- #serotonin
- #striatum
- Synchronous activation of striatal cholinergic interneurons (CINs) induces local serotonin (5-HT) release in the dorsal striatum via nicotinic acetylcholine receptors (nAChRs).
- This CIN-5-HT coupling is absent in the ventral striatum despite denser serotonergic innervation.
- The nAChR-dependent release increases 5-HT levels and expands the spatial footprint of serotonergic signaling.
- In Sapap3-/- mice (OCD model), this mechanism is exaggerated due to a hypercholinergic state, amplifying nAChR-dependent monoamine release.
- The findings highlight region-specific acetylcholine-5-HT crosstalk in the striatum and CINs' role in regulating 5-HT dynamics in health and disease.