Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut - PubMed
4 hours ago
- #intestinal disease
- #metabotherapy
- #metabolites
- Metabotherapy involves using metabolites to prevent and treat gut disorders.
- The gastrointestinal tract contains diverse small molecules from diet, microbes, and host metabolism.
- Metabolites play a direct role in various intestinal diseases, including inflammatory, metabolic, and neoplastic conditions.
- Oral intervention can fine-tune intestinal metabolite levels, offering a promising therapeutic strategy.
- Mechanisms by which metabolites influence immune cells, epithelium, and neurons in the gut are discussed.
- Metabolites are classified based on potential therapeutic intervention categories.
- Preclinical and clinical data highlight the role of metabolites in diseases like IBD, IBS, colorectal cancer, and more.
- Metabolite-based intervention strategies are explored for different gastrointestinal diseases.
- The article aims to provide a roadmap for developing metabotherapies for intestinal diseases.