Genetic causal association between kidney stones and proton pump inhibitors - PubMed
3 hours ago
- #Kidney stones
- #Proton pump inhibitors
- #Mendelian randomization
- Study investigates genetic causal association between proton pump inhibitors (PPIs) and kidney stones using Mendelian randomization (MR) analysis.
- Utilized large-scale GWAS data from UK Biobank for PPI use and FinnGen Consortium for kidney stone outcomes.
- Five MR models applied, including drug target MR (DTMR) analysis focusing on H+/K+-ATPase (ATP4A/ATP4B).
- Results show no significant causal association between genetically predicted PPI use and kidney stone risk.
- DTMR analysis also found no significant link between ATP4A/ATP4B genetic proxies and kidney stones.
- Conclusion supports safe use of PPIs in patients with gastric ulcers or GERD, with no evidence of increased kidney stone risk.