Targeting the sensory-sympathetic axis for cancer immunotherapy - PubMed
5 hours ago
- #sensory-sympathetic axis
- #β-blockers
- #cancer immunotherapy
- Recent study by Wei et al. reveals a vagal sensory-brain stem sympathetic circuit in lung adenocarcinoma that suppresses macrophages and CD8+ T cells via β2-adrenergic signaling.
- Disrupting this sensory-sympathetic axis restores antitumor immunity, suggesting β-blockers and neural modulation as promising therapies for cancer immunotherapy.
- The findings highlight how tumors manipulate neural circuits to evade immunity, emphasizing the role of cancer neuroscience and drug repurposing in targeting tumor-brain crosstalk.