Brain Organoids as Emerging Platforms for Modeling Neurodegenerative Diseases: Progress, Challenges, and Future Directions - PubMed
2 hours ago
- #brain-organoids
- #3D-modeling
- #neurodegenerative-diseases
- Brain organoids are emerging as platforms for modeling neurodegenerative diseases like Alzheimer's, Parkinson's, Huntington's, and ALS.
- Traditional models (2D cell cultures, animal models, postmortem tissue) fail to fully replicate human brain mechanisms.
- 3D brain organoids mimic human brain conditions, including neuronal-glial interactions, protein aggregation, and neuroinflammation.
- Integration of iPSCs with brain organoids bridges bench-to-bedside research, aiding in disease modeling and drug screening.
- Challenges include incomplete tissue maturation, lack of vascularization, and limited cellular diversity in organoids.
- Brain organoids provide insights into molecular and genetic mechanisms underlying neurodegenerative diseases.