Elevated MANF expression in β cells protects mice from streptozotocin-induced diabetes by attenuating islet stress and immunogenicity - PubMed
3 hours ago
- #diabetes
- #MANF
- #β cells
- Elevated MANF expression in β cells protects mice from streptozotocin-induced diabetes.
- MANF attenuates islet stress and immunogenicity, preserving β cell mass and enhancing proliferation.
- Transcriptomic profiling shows downregulation of ER and oxidative stress, inflammation, and immune response genes in MANF overexpressing islets.
- MANF suppresses terminal UPR markers like CHOP and TXNIP, reducing β cell stress.
- MANF deficiency increases Chop and TXNIP levels, exacerbating β cell stress.
- MANF is identified as a dual-acting therapeutic target for T1D, alleviating stress and reducing immunogenicity.