Role of circadian gene expression in the divergent effects of intermittent hypoxia and sleep fragmentation on blood pressure - PubMed
6 hours ago
- #Hypertension
- #Sleep Apnea
- #Circadian Clock
- Circadian clock genes regulate cardiovascular and renal functions, affecting salt sensitivity and blood pressure.
- Obstructive sleep apnea (OSA), through intermittent hypoxia and sleep fragmentation, disrupts circadian rhythms and exacerbates hypertension via hypoxia-induced gene regulation (e.g., HIF-1α).
- Moderate intermittent hypoxia conditioning may benefit heart and vasculature by modulating genes like PER2, HIF-1α, and BMAL1, offering potential new therapies for salt-sensitive hypertension and OSA.