Time matters: The prognostic impact of diagnostic delay on survival in primary central nervous system lymphoma-a single-center, retrospective real-world study - PubMed

6 days ago

Primary central nervous system lymphoma (PCNSL) is a rare and aggressive malignancy that often mimics other CNS diseases, leading to diagnostic delays.
Early diagnosis and timely treatment initiation are critical for PCNSL, but its nonspecific radiological presentation makes diagnosis challenging.
The study analyzed 125 PCNSL patients (2008-2021) to evaluate diagnostic timelines, treatment patterns, and their impact on survival.
Median time from initial symptoms to confirmed diagnosis was 37 days, and from first neuroimaging to diagnosis was 12 days.
A shorter diagnostic interval (≤12 days) was associated with significantly improved overall survival and progression-free survival (PFS).
Key predictors of overall survival (OS) included Karnofsky Performance Status (KPS) ≥70%, preserved renal function (GFR >60 mL/min), and MTX-based chemotherapy.
Diagnostic delay (>12 days) was an independent predictor of worse PFS.
MTX-based chemotherapy remains the standard of care, with autologous hematopoietic stem cell transplantation offering the best survival outcomes for eligible patients.

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