The maternal PADI6-UHRF1-UBE2D complex regulates ubiquitination during oocyte maturation and embryogenesis - PubMed
3 hours ago
- #oocyte maturation
- #embryogenesis
- #ubiquitination
- The maternal PADI6-UHRF1-UBE2D complex (MPU) regulates ubiquitination during oocyte maturation and embryogenesis.
- PADI6, a core component of cytoplasmic lattices (CPLs), forms the MPU complex with UHRF1 and UBE2D.
- The MPU complex suppresses the ubiquitination cascade by sequestering UBE2D, preventing ubiquitin transfer to substrates.
- 86% of clinically identified PADI6 missense variants disrupt MPU assembly, linking ubiquitination dysregulation to abnormal embryonic development.
- The study provides insights into PADI6's role in proteostasis regulation during oocyte maturation and early embryogenesis.