Sleep Disruption and Shift Work Associate with Increased Risk of Reproductive Endocrine Disorders: Evidence from UK Biobank and Mendelian Randomization - PubMed

4 hours ago

Sleep disruption and shift work are linked to increased risk of reproductive endocrine disorders (REDs) in women.
A U-shaped association was found between sleep duration and RED risk, with the lowest risk at 7 hours of sleep per day.
Short sleep (≤5 hours/day) and long sleep (≥9 hours/day), poor sleep quality, and night shift work independently increase RED risk.
The highest risk was observed in women with both night shift work and ≤5 hours of sleep per day.
Inflammatory biomarkers (neutrophils, CRP, leukocytes) mediate 5-13% of the associations between sleep traits, shift work, and REDs.
Mendelian randomization (MR) analyses support causal effects of short sleep duration, insomnia, and daytime napping on REDs.
The study highlights the importance of screening for sleep disturbances and shift work in RED risk assessment.
Interventions targeting sleep duration and shift work schedules may help reduce RED incidence and improve reproductive health.

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