Co-Extracellular Vesicles Delivery System Enhances Immunochemotherapy for Glioblastoma - PubMed
5 hours ago
- #Extracellular Vesicles
- #Glioblastoma
- #Immunochemotherapy
- The study develops a co-extracellular vesicles (co-EVs) delivery system for enhanced immunochemotherapy against glioblastoma (GBM).
- The system combines M0 macrophage-derived EVs (MEVs) with doxorubicin-loaded lemon-derived EVs (LEVDs) to penetrate brain barriers and target the tumor microenvironment.
- MEVs home to tumor-associated macrophages (TAMs) and deliver microRNA let-7f-5p to repolarize immunosuppressive M2 macrophages into anti-tumor M1 phenotypes.
- LEVDs target GBM cells directly via receptor-ligand interactions to enable efficient chemotherapy.
- The combined approach enhances GBM treatment by modulating the tumor microenvironment and delivering chemotherapy simultaneously.