Itaconate as a Potent Regulator of Neutrophil Responses in Host Defence and Inflammation - PubMed
10 hours ago
- #immunometabolism
- #neutrophil biology
- #inflammation regulation
- Itaconate is an immune-responsive metabolite derived from mitochondrial TCA cycle via IRG1/ACOD1.
- Its production surges in myeloid cells during infections and cancer, regulating macrophage responses.
- Neutrophils also produce itaconate, which modulates their activation, affecting pathogen clearance and inflammation.
- Mechanisms include influencing signal transduction, protein modification, and anti-inflammatory pathways like Nrf2 activation.
- Itaconate impacts neutrophil functions such as phagocytosis, ROS production, and NET formation.
- Understanding itaconate's role in neutrophils offers therapeutic potential for infectious and inflammatory diseases.