Metformin hydrochloride regulates glycolysis and inhibits PEDV replication by inhibition of PI3K-AKT signaling pathway - PubMed
4 hours ago
- #Glycolysis
- #Metformin hydrochloride
- #PEDV
- Metformin hydrochloride (MH) inhibits PEDV replication by targeting the PI3K-AKT signaling pathway.
- PEDV infection increases cellular glucose uptake and lactate production, enhancing viral replication.
- MH blocks the EGFR/PI3K/AKT/GSK3B pathway, reducing glycolysis and lactic acid production.
- MH maintains GSK3B in a non-phosphorylated state, leading to c-MYC degradation and antiviral effects.
- This study provides insights into MH's potential application in veterinary medicine for PEDV control.