Gelsolin-3: A Novel Myelin Autoantigen in Demyelinating Guillain-Barré Syndrome - PubMed
6 hours ago
- #Gelsolin-3
- #Demyelinating Guillain-Barré Syndrome
- #Autoantibody
- Identifies gelsolin-3 as a novel autoantigen targeted by IgG1 antibodies in demyelinating Guillain-Barré syndrome (GBS), particularly in acute inflammatory demyelinating polyneuropathy (AIDP) and bifacial weakness with paresthesias (BFP).
- Anti-gelsolin-3 IgG antibodies were found in 6% of GBS patients, showing strong associations with facial weakness and AIDP electrophysiological classification, with no cross-reactivity to other gelsolin isoforms.
- In vivo studies demonstrate that these antibodies bind to nodal regions, causing complement-dependent nodal injury, disruption of sodium channel clusters, and demyelination, preceding macrophage infiltration.
- Provides evidence that AIDP can be classified as a nodo-paranodopathy, establishing a unifying mechanism where nodal complement activation underlies conduction block in both axonal and demyelinating GBS subtypes.