Association of total and regional fat-to-muscle ratio with the risk of metabolic dysfunction-associated fatty liver disease and other chronic liver diseases - PubMed
5 days ago
- #body composition
- #fat-to-muscle ratio
- #liver disease
- Study examines the association between total and regional fat-to-muscle ratio (FMR) and the risk of metabolic dysfunction-associated fatty liver disease (MASLD) and other chronic liver diseases.
- Participants included 356,833 individuals from the UK Biobank, with body composition assessed via segmental bioelectrical impedance analysis (BIA).
- Higher FMR, especially in the legs for women and trunk/arms for men, was strongly associated with increased risk of MASLD, cirrhosis, liver-related mortality, and HCC.
- Sex-specific patterns were observed, with stronger associations in men for cirrhosis and liver-related mortality, while women showed stronger associations for MASLD.
- The study highlights the importance of body composition in predicting liver disease outcomes, with regional FMR providing additional insights.