Dextran-based microneedle patch Co-delivering safflower polysaccharide and ROS-responsive tetramethylpyrazine micelles for diabetic wound repair - PubMed
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- #ROS-responsive
- #diabetic-wound
- #microneedle-patch
- Development of a dextran-based microneedle patch for diabetic wound repair.
- Co-delivery of safflower polysaccharide (SPS) and ROS-responsive tetramethylpyrazine (TMP) micelles.
- The patch promotes healing through ROS-responsive release and neurovascular regeneration.
- In vitro studies show antioxidant, anti-inflammatory, pro-angiogenic, and neuroregenerative effects.
- In vivo results demonstrate accelerated wound closure in diabetic rats.
- Transcriptomic analysis reveals activation of immune modulation and neurovascular repair pathways.
- Multifunctional approach addresses persistent inflammation, oxidative stress, and compromised healing.