NF-κB activation in astrocytes impairs wound healing after traumatic brain injury in male mice - PubMed
4 days ago
- #Traumatic Brain Injury
- #Astrocytes
- #NF-kappaB
- NF-κB activation in astrocytes impairs wound healing after traumatic brain injury (TBI) in male mice.
- TBI triggers neuroinflammatory reactions involving glial cells and peripheral immune cells, influencing clinical outcomes.
- NF-κB activation disrupts astrocyte homeostatic functions, amplifies neuroimmune responses, and hinders CNS scar formation.
- Deficits in glial limitans border formation and detrimental paracrine signaling from NF-κB-activated astrocytes impair CNS integrity post-TBI.
- Findings highlight NF-κB's role in TBI pathophysiology, suggesting targeted therapies to improve recovery.