Astrocytic TIA1-Mediated Stress Granules Promote the Demyelination of Optic Neuritis by Sequestering mRNA of Cholesterol Synthesis Genes in an Experimental Autoimmune Encephalomyelitis Model - PubMed
3 hours ago
- #demyelination
- #optic neuritis
- #TIA1
- Astrocytic TIA1-mediated stress granules (SGs) contribute to demyelination in optic neuritis (ON) by sequestering mRNA of cholesterol synthesis genes.
- TIA1 knockout in CNS (Tia1Nestin-CKO mice) reduces demyelination, inflammation, and retinal ganglion cell (RGC) loss in experimental autoimmune encephalomyelitis (EAE) models.
- Cholesterol synthesis genes, such as hmgcs1, are upregulated in Tia1Nestin-CKO EAE mice.
- Deletion of Tia1 in astrocytes (Tia1GFAP-CKO mice) alleviates demyelination by reducing SG formation and increasing HMGCS1 expression.
- Treatment with diarylpropionitrile (DPN), an ERβ-ligand, partially restores demyelination in Tia1GFAP-CKO EAE mice.
- The study highlights TIA1-mediated SG dynamics as a novel mechanism and potential therapeutic target for MS-related optic neuritis.