Integrating liquid biopsies and artificial intelligence for early cancer detection: A systematic review and meta-analysis - PubMed
4 hours ago
- #artificial intelligence
- #early cancer detection
- #liquid biopsy
- Liquid biopsies combined with AI, specifically machine learning (ML), are evaluated for early cancer detection using circulating cell-free DNA (cfDNA) multi-omic features.
- A systematic review and meta-analysis included 109 studies across multiple cancer types, showing high specificity (94%-99%) and sensitivity ranging from 44% to 99% depending on cancer stage.
- Neural networks, random forest, and heterogeneous ensemble learning achieved the highest sensitivity, with fragmentomic features providing the best sensitivity compared to methylation.