Nociceptive neurons protect cancer cells against oxidative stress - PubMed
3 hours ago
- #cancer neuroscience
- #oxidative stress
- #NRF2 pathway
- Nociceptive neurons protect cancer cells from oxidative stress by secreting epiregulin.
- Epiregulin increases Lnc-GCLC-1 expression in cancer cells, activating the NRF2 pathway.
- Lnc-GCLC-1 disrupts KEAP1-NRF2 interaction, enhancing glutathione (GSH) biosynthesis.
- This mechanism protects head and neck squamous cell carcinoma (HNSCC) cells from cisplatin-induced oxidative stress.
- Targeting nociceptive neurons or the EREG-Lnc-GCLC-1-NRF2 axis improves cisplatin's therapeutic efficacy.
- High Lnc-GCLC-1 levels correlate with poor prognosis in HNSCC patients.