RNF213 Is an Interferon-Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection - PubMed
4 hours ago
- #MDA5
- #RNF213
- #Influenza A Virus
- RNF213 is identified as an interferon-stimulated gene (ISG) that inhibits Influenza A Virus (IAV) replication.
- RNF213 knockout mice show increased susceptibility to IAV infection, indicating its critical role in antiviral defense.
- RNF213 enhances IFN production by promoting MDA5 signaling through K63-linked polyubiquitination at specific lysine residues.
- RNF213 mediates K48-linked polyubiquitination of viral nucleoprotein (NP), leading to its proteasomal degradation.
- The study highlights RNF213's dual mechanism in antiviral immunity, acting both in innate immune activation and direct viral restriction.