Structural characterization and anti-aging mechanism of Codonopsis pilosula polysaccharides - PubMed
7 hours ago
- #anti-aging
- #polysaccharides
- #gut microbiota
- The study involves the structural analysis and anti-aging effects of polysaccharides from Codonopsis pilosula (CPPS), which is a neutral heteropolysaccharide with a molecular weight around 6.423 kDa (Mn) and composed mainly of fructose and glucose.
- CPPS demonstrates significant anti-aging activity in D-gal-induced aging mice by improving cognitive function and reducing oxidative stress and inflammation in the hippocampus and liver tissues.
- Mechanistically, CPPS influences gut microbial metabolites and repairs intestinal barrier damage, as shown by 16S rRNA analysis and metabolomics, and it regulates the JAK2-STAT3 signaling pathway to inhibit microglia activation, linked to the tryptophan metabolite 3-indole-glyoxylic acid.