Ceftazidime-avibactam resistance evolution in Pseudomonas aeruginosa and implications for cross-resistance to other novel β-lactams - PubMed
5 hours ago
- #β-lactams
- #Pseudomonas aeruginosa
- #antibiotic resistance
- Ceftazidime-avibactam resistance evolution in Pseudomonas aeruginosa was studied using 12 patient isolate pairs.
- Resistance mechanisms included amino acid substitutions in AmpC and OXA β-lactamases, and regulatory mutations causing hyper-production of AmpC and MexAB-OprM efflux pumps.
- Cross-resistance was common with ceftolozane-tazobactam, less common with imipenem-relebactam and cefepime-zidebactam, and lowest with cefiderocol.
- Findings have important implications for sequential treatment of P. aeruginosa infections.