CDH1, CAV1, NR3C1, and ZEB1 are Potential Biomarkers in Colorectal Cancer Drug Resistance and Prognosis - PubMed
3 days ago
- #Biomarkers
- #Colorectal Cancer
- #Drug Resistance
- CDH1, CAV1, NR3C1, and ZEB1 identified as potential biomarkers for colorectal cancer (CRC) drug resistance and prognosis.
- Study utilized bioinformatics analysis (GEO database GSE153412) to screen differentially expressed genes (DEGs) between 5-FU-resistant and sensitive CRC cells.
- Gene set enrichment analysis (GSEA), WGCNA, and PPI networks were used to identify resistance-related modules and hub genes.
- Key genes (CAV1, CDH1, CXCL8, CD24, NR3C1, ZEB1) were found to be related to CRC prognosis in TCGA-COAD datasets.
- Clinical validation confirmed the dysregulation of CDH1, CAV1, NR3C1, and ZEB1 in CRC samples, supporting their role in drug resistance pathways.