Urolithin a alleviates airway inflammation in acute allergic asthma by suppressing the EGFR/AKT/FOXO3a signaling pathway - PubMed
8 hours ago
- #NLRP3 Inflammasome
- #Allergic Asthma
- #Urolithin A
- Urolithin A (UroA) alleviates airway inflammation in acute allergic asthma by targeting the EGFR/AKT/FOXO3a pathway.
- UroA, a metabolite of ellagic acid, shows anti-inflammatory and antioxidant effects.
- Study uses OVA-induced asthma mouse model and LPS-stimulated 16HBE cells to demonstrate UroA's effects.
- UroA suppresses NLRP3 inflammasome activity in both cells and lung tissue.
- Mechanism involves inhibition of EGFR-mediated AKT/FOXO3a phosphorylation, similar to effects of EGFR inhibitor erlotinib.
- Findings suggest UroA as a potential therapeutic candidate for acute allergic asthma.