Association between the triglyceride-glucose index and risk of type 2 diabetes mellitus and the mediating effect of BMI: a comparative analysis in Chinese and Japanese populations - PubMed
3 hours ago
- #BMI mediation
- #type 2 diabetes
- #TyG index
- The study examines the association between the triglyceride-glucose (TyG) index and the risk of type 2 diabetes mellitus (T2DM) in Chinese and Japanese adults.
- It aims to quantify the mediating role of body mass index (BMI) in the TyG-diabetes association.
- Data from the China Rich Healthcare Group (n=199,050) and the Japanese NAGALA database (n=15,464) were analyzed.
- TyG was calculated using fasting triglycerides and fasting plasma glucose levels.
- Incident T2DM was defined according to American Diabetes Association criteria.
- Multivariable Cox models and mediation analysis were used to assess associations and mediation effects.
- Results showed that higher TyG was associated with increased T2DM risk in both populations, with BMI partially mediating this association (19.06% in Chinese vs 14.22% in Japanese adults).
- Nonlinear analyses identified cohort-specific inflection points for TyG levels associated with higher diabetes risk.
- TyG showed moderate discrimination for 5-year diabetes risk, outperforming triglycerides alone but less discriminative than fasting plasma glucose.
- The study highlights population-specific differences in metabolic pathways and the need for tailored risk stratification based on TyG.