Macrophage extracellular traps in autoimmunity: In vivo definition, pathogenic circuits, and therapeutic targeting - PubMed
4 hours ago
- #Autoimmunity
- #Macrophage extracellular traps
- #Therapeutic targeting
- Macrophage extracellular traps (METs) are chromatin-based scaffolds involved in inflammation and autoantigen externalization.
- METs are linked to autoimmune activity and organ injury, contributing to diseases like rheumatoid arthritis and lupus.
- METs expose modified chromatin and mitochondrial DNA, potentially driving autoantibody responses such as ACPA and anti-dsDNA.
- The review proposes a checklist for in vivo MET identification to improve study comparability.
- Three therapeutic strategies are outlined: limiting MET induction, accelerating clearance, and dampening DNA-sensing pathways.
- The study highlights translational challenges, including host-defense trade-offs and biomarker-guided therapy selection.