Nuclear prostaglandin E synthase 3 promotes hepatocellular carcinoma growth with immunosuppressive macrophage polarization via the SP1/TGF-β axis - PubMed
3 hours ago
- #Macrophage polarization
- #PTGES3
- #HCC
- PTGES3 is upregulated in hepatocellular carcinoma (HCC) and linked to poor prognosis.
- PTGES3 silencing in hepatocytes reduces tumorigenesis in an HCC mouse model.
- PTGES3 deficiency alters the immune landscape by reducing tumor-associated macrophage infiltration and M2 polarization.
- PTGES3 binds to a specific motif on the SP1 promoter, driving SP1-mediated TGF-β secretion.
- This PTGES3/SP1/TGF-β axis promotes both immunosuppressive macrophage polarization and tumor cell proliferation via autocrine signaling.