Comprehensive Genomic and Transcriptomic Analysis to Guide Therapy for Patients with Metastatic Solid Tumors - PubMed
3 hours ago
- #genomic profiling
- #transcriptomic analysis
- #precision oncology
- Comprehensive genomic and transcriptomic profiling (CGTP) with whole exome sequencing (WES) and whole transcriptome sequencing (WTS) was evaluated for its clinical utility compared to conventional targeted panel sequencing in patients with metastatic solid tumors.
- The study involved 99 patients with advanced cancers across 19 tumor types who had prior panel sequencing without actionable DNA alterations.
- CGTP identified actionable genomic alterations in 69.7% of cases and actionable transcriptomic alterations in 100% of cases.
- When integrated into routine care, biomarker-matched therapy was administered to 19.2% of patients based on CGTP findings.