Intravenous immunoglobulin remodels innate immune cell communication and induces differential autophagy pathways in Kawasaki disease - PubMed
7 hours ago
- #IVIG
- #Kawasaki disease
- #autophagy
- Intravenous immunoglobulin (IVIG) is a first-line immunotherapy for Kawasaki disease (KD) and other inflammatory diseases.
- IVIG induces autophagy in inflammatory innate immune cells, but its selective activation across different cell subsets was unclear.
- Single-cell RNA sequencing revealed IVIG reshapes innate immune composition and restores immune networks in KD patients.
- IVIG upregulates macroautophagy genes (e.g., ATG7, UVRAG) in monocytes and induces selective autophagy pathways in a cell-type-specific manner.
- Mechanistic studies showed IVIG-induced autophagy occurs independently of Fc fragments and C-type lectin receptors.
- IVIG's therapeutic effects in KD may involve remodeling innate immune communication and activating differential autophagy programs.