Models of the human heart for biomedical research: Opportunities and challenges - PubMed
4 hours ago
- #Human Heart Models
- #Cardiovascular Research
- #Tissue Accessibility
- Animal models are vital but have limited translatability to humans, necessitating human model systems like stem cells, 3D constructs, and native tissues.
- Access to healthy human heart tissue is scarce, often restricted to diseased hearts, with legal hurdles hindering use of non-transplanted donor organs.
- An integrated strategy combining non-human models, in silico models, and human tissue-derived models is recommended to bridge preclinical and clinical research gaps.