High-dimensional immune profiling of atopic dermatitis reveals a dysfunctional OX40+ regulatory T cell subset - PubMed
a day ago
- #OX40
- #Atopic dermatitis
- #Regulatory T cells
- Atopic dermatitis (AD) affects up to 10% of the global population and is characterized by chronic inflammation and intense itching.
- The study used high-dimensional immune profiling (CyTOF) to analyze PBMCs from 48 AD patients and 48 healthy controls.
- A distinct dysfunctional OX40+CRTH2+ regulatory T cell (Treg) subset was identified in AD patients, correlating with disease severity.
- These OX40+ Tregs showed a Th2-skewed transcriptional signature and reduced suppressive capacity compared to healthy controls.
- The findings suggest OX40+ Tregs as key drivers of immune imbalance in AD, supporting OX40-targeted therapies.