Gut microbiome and bile acid metabolism in liver disease: Mechanisms, clinical implications, and therapeutic opportunities - PubMed
3 hours ago
- #bile acid metabolism
- #liver disease
- #gut microbiome
- The gut microbiome and bile acid metabolism are crucial for liver health via the gut-liver axis.
- Disruptions in this axis contribute to liver diseases like metabolic dysfunction-associated steatotic liver disease, alcohol-associated liver disease, cholestatic diseases, and liver cancer.
- Bile acids act as signaling molecules through receptors such as farnesoid X receptor (FXR) and G-protein-coupled receptors.
- Disease-specific changes in gut microbiota and bile acid profiles are linked to liver injury and progression.
- Potential diagnostic and prognostic biomarkers include microbiome signatures and bile acid profiles.
- Therapeutic strategies targeting the gut-liver axis include probiotics, fecal microbiota transplantation, FXR agonists, and fibroblast growth factor 19 analogs.
- Future research should focus on multiomics integration, functional studies, and personalized medicine for liver disease management.