Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating - PubMed
3 hours ago
- #signal transduction
- #fission yeast
- #MAPK cascade
- Sms1 is identified as a novel scaffold for the MAPK cascade in fission yeast, essential for sexual differentiation.
- Sms1 interacts with PIP2 and the pheromone receptor-coupled Gα subunit, targeting it to plasma membrane patches to assemble the active MAPK cascade.
- Phosphorylation, including by the MAPK itself, regulates Sms1 membrane translocation, establishing a negative feedback mechanism.
- This feedback mechanism is crucial for polarity patch turnover and preventing premature mating attempts.
- Sms1's role highlights convergent evolution of MAPK scaffolds across eukaryotes despite its distinct structural fold.