Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage - PubMed
3 days ago
- #ribosomal modifications
- #neural crest
- #neuroblastoma
- Ribosomal modifications are linked to mesenchymal fate selection in neural crest cells.
- Mesenchymal fate commitment correlates with rRNA-modifying and ribosome assembly factors, not structural ribosomal proteins.
- Key post-transcriptional modifications in 18S rRNA involve EMG1, NHP2, and TSR3.
- Disruption of NHP2 or TSR3 affects cranial neural crest differentiation in vitro and in vivo.
- Temporal knockout of Polr1a or Polr1c post-migration leads to craniofacial malformations.
- Cell type-specific m¹acp³Ψ levels vary during neural crest differentiation.
- Elevated ribosomal control and rRNA-modifying proteins predict poorer outcomes in neuroblastoma patients.
- TSR3 and WDR74 play functional roles in mesenchymal-like tumor states in neuroblastoma cell lines.
- Ribosomal heterogeneity influences both normal development and tumor progression.