Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC - PubMed
4 days ago
- #TNBC
- #mRNA vaccine
- #T cell immunity
- Individualized mRNA vaccines were tested in 14 TNBC patients post-surgery and therapy.
- High-magnitude, durable T cell responses to neoantigens were observed in most patients.
- T cells developed into cytotoxic effector and stem cell-like memory phenotypes.
- 11 patients remained relapse-free for up to six years post-vaccination.
- Three patients relapsed, with insights into immune escape mechanisms provided.
- The study demonstrates the feasibility of individualized RNA vaccines in TNBC.