Coordinating meiotic prophase i progression and early oocyte differentiation - PubMed
7 hours ago
- #TAF4b
- #Meiosis
- #Oogenesis
- Female reproductive senescence is due to the depletion of the ovarian reserve, a finite pool of oocytes established during fetal development.
- Oocytes in the ovarian reserve remain quiescent for decades before activation in adulthood.
- Developmentally competent oocytes must successfully initiate meiosis and oogenesis to populate the ovarian reserve.
- The transcriptional regulator TAF4b plays a crucial role in meiotic prophase I progression in mouse fetal oocytes.
- TAF4b-deficient oocytes enter meiosis I on time but show compromised progression through the pachytene-to-diplotene transition.
- TAF4b-deficient oocytes have reduced ability to repair double-strand DNA breaks.
- Transcriptional profiling shows TAF4b-deficient oocytes fail to properly coordinate meiotic gene reduction and oocyte differentiation gene activation between E16.5 and E18.5.