A sequential defense-nourishment strategy enabled by thermosensitive core-shell microneedles for synergistic tendon repair - PubMed
7 hours ago
- #tissue-engineering
- #tendon-repair
- #microneedles
- Innovative thermosensitive core-shell microneedles designed for Achilles tendon repair.
- Core contains growth factor-rich platelet-rich plasma (PRP) for tissue regeneration.
- Shell loaded with proanthocyanidin-copper (PCCu) for antioxidant and antibacterial effects.
- Temperature-responsive hydroxybutyl chitosan (HBC) matrix enables stable anchoring and sustained release.
- PCCu rapidly clears ROS and inhibits bacteria, creating an anti-inflammatory microenvironment.
- PRP provides programmed release of growth factors to support tendon stem cell proliferation.
- In vitro tests confirmed antioxidant, antibacterial, and tenogenic differentiation promotion.
- In vivo rat model showed reduced inflammation and improved collagen fiber alignment.
- Enhanced biomechanical strength and functional regeneration of tendon defects achieved.
- First combination of thermosensitive microneedles with a sequential defense-nourishment strategy.