Effect of diet intervention on symptoms in autism spectrum disorder: An umbrella review - PubMed
4 hours ago
- #Diet Intervention
- #Umbrella Review
- #Autism Spectrum Disorder
- The study evaluated dietary interventions' efficacy in improving ASD symptoms through an umbrella review.
- 15 meta-analyses covering 118 clinical studies with 5033 ASD patients (ages 1.5-45) were included.
- Primary interventions: gluten-free and casein-free (GFCF) diets, probiotics, Vitamin D, and PUFAs.
- Dietary interventions significantly improved overall symptoms, communication, social interaction, and hyperactivity.
- Vitamin D showed the most significant effect on overall ASD symptoms (SMD = -0.45).
- No significant improvement in stereotypical behavior, irritability, lethargy, and inappropriate speech.
- Future research needed on neurobiological mechanisms, safety, and objective indicators like gut microbiota.