PRRSV-2 impedes lysosomes from eliminating secondary infected bacteria - PubMed
3 hours ago
- #PRRSV-2
- #secondary bacterial infection
- #lysosome dysfunction
- PRRSV-2 infection disrupts intracellular F-actin, impairing lysosome transport to secondary infected bacteria for clearance.
- RhoA is essential for F-actin polymerization; its silencing delays bacterial clearance, while overexpression accelerates it.
- PRRSV-2 downregulates RhoA via nsp5, which interacts with Smurf1 to mediate RhoA ubiquitination and degradation via the autophagy-lysosome pathway.
- This study reveals a mechanism by which PRRSV-2 reprograms the cytoskeleton to aid bacterial survival in secondary infections.