Striking a nerve: Sensory neurons orchestrate ECM remodeling and immune exclusion in TNBC - PubMed
a day ago
- #immunotherapy
- #TNBC
- #tumor microenvironment
- Sensory neurons play a key role in the tumor microenvironment of triple-negative breast cancer (TNBC).
- A signaling circuit involving cancer cells, sensory neurons, and cancer-associated fibroblasts promotes desmoplasia (ECM remodeling).
- This neuron-fibroblast axis leads to immune exclusion by blocking cytotoxic T cells.
- The study suggests targeting this axis could be a therapeutic strategy and predictor of immunotherapy response.
- The authors declare no competing interests.