Tirzepatide attenuates mesolimbic cocaine-evoked dopamine levels and reduces cocaine taking, motivation and seeking behaviours in male rodents - PubMed
6 hours ago
- #Tirzepatide
- #Dopamine Regulation
- #Cocaine Use Disorder
- Tirzepatide reduces cocaine self-administration and cocaine-evoked dopamine responses in male rodents.
- The drug diminishes motivation for cocaine and attenuates relapse behaviors such as reinstatement and locomotor sensitization.
- Neurochemical analyses show tirzepatide normalizes cocaine-induced dopamine, GABA, and glutamate changes in mesolimbic circuits.
- The study suggests tirzepatide may be a potential treatment for cocaine use disorder due to its multi-receptor agonist properties.