Proteomic landscape of Ewing sarcoma primary tumors and metastases - PubMed
a day ago
- #cancer biology
- #proteomics
- #Ewing sarcoma
- Deep mass spectrometry-based proteomic analysis of 170 Ewing sarcoma (EWS) tumor samples from 74 patients.
- Analysis of over 10,000 proteins provides insights into cancer prognosis, chemo-resistance, and progression.
- Ferroptosis pathways may be linked to chemotherapy response in EWS.
- Molecular subclasses correlate tumor immune landscape with DNA damage repair, ubiquitin-related proteins, and patient outcomes.
- Multiplexed immunofluorescence suggests neutrophils may indicate poorer prognosis, while macrophages/T cells suggest a more favorable prognosis.
- The study offers insights into EWS biology, aiding in the development of therapeutic strategies.