A dual role for ER-Golgi cargo receptor LMAN1 in supporting CSFV replication and restraining RLR signaling - PubMed
8 hours ago
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- #RLR-MAVS pathway
- #CSFV
- LMAN1, an ER-Golgi cargo receptor, plays a dual role in supporting CSFV replication and restraining RLR signaling.
- CSFV infection upregulates LMAN1 expression in pigs and PK-15 cells, which is essential for efficient viral proliferation.
- LMAN1 directly interacts with CSFV's RNA-dependent RNA polymerase NS5B via its carbohydrate recognition domain (CRD), aiding viral replication complex formation.
- LMAN1 deficiency hyperactivates the RLR-MAVS pathway, enhancing IRF3 and NF-κB p65 phosphorylation and interferon-β production.
- The CRD domain of LMAN1 is crucial for suppressing interferon responses, modulating antiviral signaling via the RLR-MAVS pathway.
- LMAN1 is identified as a host factor exploited by CSFV for replication and immune evasion, presenting a potential antiviral target.