PD-1 blockade plus tyrosine kinase inhibitor remodels the tumor microenvironment in advanced renal cell carcinoma - PubMed
4 hours ago
- #tumor microenvironment
- #immunotherapy resistance
- #renal cell carcinoma
- Combination of TKIs and ICIs improves outcomes in advanced renal cell carcinoma, but resistance persists.
- Single-cell analysis showed non-responders had increased neutrophil infiltration and SAA+ tumor cells.
- A VEGFA+CEACAM1+ neutrophil subset with immunosuppressive properties was linked to poor response.
- Blocking the SAA-CEACAM1-TIM-3 axis enhanced therapy efficacy in models.
- The study identifies new targets to overcome resistance in renal cell carcinoma treatment.