Tanshinone IIA-pretreated mesenchymal stem cells alleviate neuroinflammation in 3×Tg-AD mice via the TREM2/PI3K/Akt pathway - PubMed
3 hours ago
- #Mesenchymal stem cells
- #Neuroinflammation
- #Alzheimer’s disease
- Tanshinone IIA-pretreated mesenchymal stem cells (TIIA-MSC) show superior anti-neuroinflammatory effects compared to ordinary MSC.
- TIIA-MSC improves cognitive function, brain glucose metabolism, and synaptic/mitochondrial structures in 3×Tg-AD mice.
- TIIA-MSC inhibits microglial activation and proinflammatory factor release via the TREM2/PI3K/Akt pathway.
- Knockdown of TREM2 weakens the anti-inflammatory effects of TIIA-MSC, highlighting its central role.
- TIIA-MSC promotes microglial transformation from proinflammatory to neuroprotective states via TREM2/PI3K/Akt activation.
- The study provides a basis for MSC application in treating neurodegenerative diseases.